Major Employers
| Employer | Product/Service | # Employees |
| Southern Illinois University | Education-Higher Education | 7,100 |
| Memorial Hospital of Carbondale | Medical | 1,116 |
| NeuroRestorative | Rehabilitation | 510 |
| Wal-Mart Carbondale | Retail-General | 400 |
| Southern Illinois Healthcare | Healthcare Administration | 376 |
| Penn Aluminum International | Manufacturing-Aluminum Extrusion | 300 |
| Illinois Department of Transportation | Government-State | 290 |
| City of Carbondale | Government-Municipal | 270 |
| St. Joseph Memorial Hospital | Medical | 250 |
| Murphysboro Unit School District 186 | Education-Primary & Secondary | 250 |
| Vitamin World | Mail Order Vitamins / Call Center | 220 |
| Brehm Preparatory School | Education-Primary and Secondary | 200 |
| Com-Pac International | Manufacturing-Poly Packaging | 180 |
| Schnucks | Retail-Grocery | 180 |
| Shawnee Health Service | Medical | 165 |
| Lowe’s | Retail-Home Improve | 160 |
| Specialized Training for Adult Rehab | Service-Various | 160 |
| Tri County Education Center | Education-Primary & Secondary | 150 |
| Southern Illinoisan Newspaper | Publishing-Newspaper | 140 |
| Southern Illinois Regional Social Services | Social Services | 130 |
| Center for Medical Arts | Medical | 121 |
| Intertape Polymer Group | Manufacturing-Specialty Tape | 75 |
| Macys | Retail-Apparel | 140 |
| City of Murphysboro | Government-Municipal | 62 |